Table 2.
Clinical and Angiogenic Factor Data of Groups Who Provided Blood for Cell Culture Analysesa
| Normotensive Controls (n = 12) | Preeclampsia (n = 11) | P Value | |
|---|---|---|---|
| Age (years) | 25.9 ± 4.7 | 26.8 ± 6.6 | .71 |
| BMI prepregnancy (kg/m2) | 28.0 ± 7.9 | 28.0 ± 5.0 | .99 |
| Gestational weeks at delivery | 39.3 ± 2.1 | 35.5 ± 3.8 | .03 |
| Gestational weeks at venipuncture | 35.7 ± 5.1 | 35.0 ± 3.9 | .52 |
| Early pregnancy blood pressureb | |||
| Systolic (mm Hg) | 110 ± 10 | 118 ± 6 | .07 |
| Diastolic (mm Hg) | 69 ± 8 | 73 ± 7 | .30 |
| Predelivery blood pressure | |||
| Systolic (mm Hg) | 117 ± 13 | 156 ± 10 | <.0001 |
| Diastolic (mm Hg) | 74 ± 8 | 96 ± 11 | <.0001 |
| Uric acid (mg/dL) | 4.8 ± 1.0 | 6.4 ± 1.3 | .003 |
| Birth weight (g) | 3445 ± 540 | 2674 ± 1138 | .06 |
| Birth weight centile | 59 ± 23 | 46 ± 37 | .35 |
| In labor during venipuncture (%) | 0% | 0% | 1.0 |
| Race (% black) | 25% (3/12) | 36% (4/11) | .67 |
| Plasma angiogenic factors | |||
| sFlt-1 (pg/mL) | 3120 (1462–11 372) | 26 629 (11 472–68 912) | <.001 |
| PlGF (pg/mL) | 106 (34–890) | 40 (3–199) | <.005 |
Abbreviation: BMI, body mass index.
a
Continuous variables are given as mean (standard deviation). Soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF) concentrations are given as median (range).
b
Average of gestational blood pressures recorded before 20 weeks of gestation.