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IC50 Values (μM) of 6 – 9 on Luciferase Expression from the HIF-1-Regulated pHRE-TK-Luc and Control (pGL3-control) Constructs (one experiment in triplicate).
| Hypoxia (1% O2) | 1,10-phen (10 μM) | |||||
|---|---|---|---|---|---|---|
| T47D | PC-3 | T47D | PC-3 | |||
| pHRE3-TK- luc (HIF) |
pGL3- control |
pHRE3-TK- luc (HIF) |
pHRE3-TK- luc (HIF) |
pGL3- control |
pHRE3-TK- luc (HIF) |
|
| 6 | 2.9 | >30 | >30 | 10.9 | >30 | >30 |
| 7 | 0.4 | 2.6 | 0.5 | 0.2 | 1.6 | 0.8 |
| 8 | 2.7 | > 30 | 7.7 | 1.0 | 23.0 | 9.0 |
| 9 | 0.5 | > 10 | 0.9 | 0.2 | 2.6 | 1.0 |
