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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Biochim Biophys Acta. 2010 Apr 11;1802(7-8):632–638. doi: 10.1016/j.bbadis.2010.04.001

Fig. 2.

Fig. 2

Treatment of male LmnaH222P/H222P mice with SP600125 inhibits expression of natriuretic peptides and myosin chains. Quantitative real-time RT-PCR showing the expression of (A) mRNAs from NppA and NppB genes encoding natriuretic peptide precursors A and B, respectively and (B) mRNAs from Myh7 encoding myosing heavy chain and Myl4 and Myl7 encoding myosin light chain. Results from hearts from Lmna+/+ mice are shown for comparison. Bars indicate the fold over-expression of the indicated mRNA calculated by the ΔΔCT method. Values are means ± standard errors for n=5 samples from different animals per group. Reactions were performed in triplicate for each different RNA sample. Comparison between DMSO-treated LmnaH222P/H222P and Lmna+/+ mice was performed using Student unpaired t-test; *P<0.05, **P<0.005, ***P<0.0005. Comparison between SP600125-treated and DMSO-treated LmnaH222P/H222P was performed using Student unpaired t-test; ‡P<0.05, ‡‡P<0.005.