Fig. 3.

In vivo dynamic MR imaging of tumors is shown at 10 minutes and at 12, 24 and 48 hours following injection of Gd-DTPA-anti-VEGFR2 antibody conjugate (A-E) as well as injection of Gd-DTPA-anti-rat IgG (F-J). Both contrast agents were injected at same dose. Gd-DTPA-anti-VEGFR2 antibody conjugate shows significant signal enhancement and accumulation in tumor tissues until 48 hours after contrast agent injection. Comparatively, Gd-DTPA-anti-rat IgG shows no significant enhancement in T1 until 48 hours after injection.