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Recognition of the MHC class II–CLIP complex in autologous GVHD. Autologous GVHD effector T cells recognize MHC class II antigens presenting a peptide from the invariant chain, termed CLIP. In addition to recognition of the MHC class II binding domain of CLIP, the N-terminal flanking domain appears to interact with the Vβ chain of the T cell receptor at or near the binding site for the SEB super antigen
