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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Pflugers Arch. 2010 Apr 10;460(2):481–494. doi: 10.1007/s00424-010-0826-0

Fig. 6.

Fig. 6

APP processing is dependent on InsP3R. a Stable expression of PS1-WT and PS1-M146L proteins in wild-type (WT) and InsP3R-deficient (KO) DT40 cell lines that stably expressed APPSWE. Actin probed as loading control. b ELISA measurements of Aβ40 (top), Aβ42 (middle), and Aβ42/Aβ40 ratio (bottom) secreted over 48 h by InsP3R-expressing wild-type (WT; left) or InsP3R-deficient (KO DT40 cells; right) DT40 cells stably expressing APPSWE alone (blue) or APPSWE with PS1-WT (red) or PS1-M146L (green). Asterisks, p< 0.01 compared with control WT cells. Cross, p<0.01 compared with control WT cells; double cross, p<0.01 compared with PS1-WT cells. From [10] with permission from Elsevier