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. Author manuscript; available in PMC: 2010 Jun 29.
Published in final edited form as: Curr Gene Ther. 2009 Dec;9(6):503–510. doi: 10.2174/156652309790031094

Figure 1. Antibody formation was associated with reduced plasma hGAA in vector-treated GAA-null mice.

Figure 1

The choice of promoter influenced antibody formation following AAV2/8 vector administration [31]. Idealized curves showing hGAA in plasma (A) and antibodies detected by ELISA (B). AAV-LSPhGAA, containing the liver-specific regulatory cassette, prevented antibody formation and produced sustained plasma hGAA elevation. AAV-CBhGAA, containing the ubiquitously active CB regulatory cassette, provoked antibody formation and produced transient plasma hGAA elevation.