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. Author manuscript; available in PMC: 2010 Jun 29.
Published in final edited form as: Curr Gene Ther. 2009 Dec;9(6):503–510. doi: 10.2174/156652309790031094

Figure 2. Treg cell mediated induction of immune tolerance in response to stimulation by NKT cells or by Kupffer cells.

Figure 2

Treg cells induce immune tolerance through suppression of activated dendritic cells to reduce CD4+ lymphocyte help, thereby impairing CTL and reducing antibody responses. Naïve CD4+ T cells interact with liver sinusoidal endothelial cells, and could assume an anti-inflammatory phenotype [57]. Similarly, Kupffer cells and/or NKT cells might stimulate Treg cells in the liver to induce immune tolerance, resulting in the suppression of dendritic cell activation in the spleen [59; 60].