Table 1.

The comparison with related studies

	Adverse Event- Drug	Drug Target Prediction					Protein target- Toxicity				PKI-Specific Input Data Size
	Literature	Physical Kinome	Literature	Chemical Structure	Compt. Prediction	Evaluation	Kinome-wide Analysis	Literature	Compt. Prediction	Evaluation	Adverse Events(#)	Kinase Inhibitors(#)	Kinase targets(#)
Studies Focusing on kinaes Toxicities
Present study	▪	▪					▪		▪	C,M	71	20	266
General Studies predicting target Toxicities (not focused on kinases)
Hansen 2009[9]				▪	▪	B			▪		3	1*	-
Bender A, et al. 2007[10]	▪			▪	▪				▪		166	-	0*
DART 2003[11]	▪		▪					▪			187	-	-
Apic 2005 [12]	▪							▪			-	-	-
Studies predicting drug targets, but not their Toxicities							Not Applicable
Fliri 2007 [13]			▪	▪		C,B					5,923	2*	168*
Garten 2009 [14]			▪								395*(a)	21*(b)	121*(c)
Liebovitch 2007 [15]	▪										-	-	-
Campillos M, et al. 2008[16]	▪			▪	▪	B					727	3*	-

C=computational evaluation, B=biological validation, M= manual curation,

^#count,

^*: subset of gene targets with protein kinase activity (GO:0004672) or subset of drugs that are kinase inhibitors;

-: no specific detail about the input data

^(a)by searching the key words “side effect” in the Pharmspresso on line database (http://pharmspresso.stanford.edu/ygarten/Pharmspresso/html/index.html)

^(b)by searching the key words “human”, “kinase” and “Inhibitor” in the Pharmspresso on line database

^(c)by searching the key words “human” and “kinase” in the Pharmspresso on line database