Figure 2. IL-12 and IFNα induce, enhance or sustain the expression of genes involved in effector functions.
Time courses for expression of selected genes regulated by IL-12 and IFNα are shown. Expression is shown as the fold change in signal intensities upon stimulation with Ag-B7 alone () or with IL-12 (ν) or IFNα (○) compared to the signal intensity for the gene in naïve cells (0 hr). (Note: different scales are used on y-axis for each gene, and scale breaks are included on the y-axis for IFNγ and CCR5).