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. Author manuscript; available in PMC: 2011 May 28.
Published in final edited form as: Circ Res. 2010 Apr 8;106(10):1582–1591. doi: 10.1161/CIRCRESAHA.109.213975

Figure 1. The spatially-distributed Ca cycling model.

Figure 1

A. Schematic plots (side view and top view) of a coupled CRU network. B. A detailed illustration of a CRU. C. A simplified Markov model of the LCC. “O” is the open state and “I” and “C” are the closed states. The LCC is activated by voltage and inactivated by voltage and Ca (as indicated by “Ca” in the graph) in the dyadic space. D. The Markov model of the RyR from Stern et al 27. “O” is the open state, “I”, “R”, and “C” are the closed states. RyR is activated and inactivated by Ca (as indicated by “Ca” in the graph) in the dyadic space.