Table 2.
Flash | Parameters | Healthy Volunteers | Diabetic | p values | |||
---|---|---|---|---|---|---|---|
Without CAN | With CAN | p1 | p2 | p3 | |||
Number of subjects | 16 | 15 (9 Type 1, 7 Type 2) |
5 (2 Type 1, 3 Type 2) |
- | - | - | |
Gender (M/F) | 9/7 | 14/1 | 4/1 | - | - | - | |
Age (years) | 44 ± 13 | 51 ± 11 | 49 ± 4 | ns | ns | ns | |
Duration of diabetes (years) | - | 20 ± 11 | 20 ± 15 | - | - | ns | |
HbA1c (%) | - | 8.3 ± 1.1 | 10.2 ± 2.1 | - | - | ns | |
Systolic blood pressure (mmHg) | 120 ± 13 | 143 ± 20 | 145 ± 14 | * | * | ns | |
Diastolic blood pressure (mmHg) | 74 ± 6 | 78 ± 9 | 86 ± 8 | ns | * | ns | |
10th | Ratio P/I preceding the 10th flash | 0.33 ± 0.050 | 0.26 ± 0.024 | 0.28 ± 0.071 | $ | ns | ns |
Latency to constriction (s) | 0.35 ± 0.139 | 0.42 ± 0.126 | 0.44 ± 0.192 | ns | ns | ns | |
Latency to largest constriction (s) | 0.68 ± 0.165 | 0.75 ± 0.133 | 0.68 ± 0.293 | ns | ns | ns | |
Ratio P/I at largest constriction | 0.28 ± 0.049 | 0.24 ± 0.021 | 0.27 ± 0.076 | * | ns | ns | |
25th | Ratio P/I preceding the 25th flash | 0.32 ± 0.044 | 0.26 ± 0.022 | 0.30 ± 0.062 | # | ns | ns |
Latency to constriction (s) | 0.31 ± 0.125 | 0.36 ± 0.070 | 0.40 ± 0.155 | ns | ns | ns | |
Ratio P/I at largest constriction | 0.27 ± 0.046 | 0.23 ± 0.020 | 0.25 ± 0.063 | ns | ns | ns | |
Latency to largest constriction (s) | 0.69 ± 0.123 | 0.72 ± 0.054 | 0.79 ± 0.138 | ns | ns | ns | |
Ratio P/I of plateau | 0.30 ± 0.041 | 0.25 ± 0.021 | 0.28 ± 0.060 | $ | ns | ns | |
Latency to plateau (s) | 0.95 ± 0.168 | 0.95 ± 0.082 | 1.35 ± 0.583 | ns | # | # | |
Duration of constriction (s) | 0.64 ± 0.237 | 0.59 ± 0.145 | 0.95 ± 0.675 | ns | ns | ns |
[mean ± standard deviation] for the 25 flashes experiment. p1 - Comparison between healthy volunteers and diabetic subjects without CAN. p2 - Comparison between healthy volunteers and diabetic subjects with CAN. p3 - Comparison between diabetic subjects without and with CAN. ns - not significant, * - p < 0.05, # - p < 0.01, and $ - p < 0.001.