Table 1.

Histological assessment of IL-6−/− vs. IL-6+/+ livers following CCl₄ administration

Score	Centrilobular necrosis	Inflammation in centrilobular areas
0	None	None
1	Isolated necrotic hepatocytes or single row of hepatocyte drop-out in perivenular areas	Mild: inflammatory infiltrate affecting <50% centrilobular areas
2	>1 and up to 3 rows of perivenular necrotic hepatocytes	Moderate: inflammatory infiltrate affecting >50% and <75% centrilobular areas
3	>3 rows of perivenular necrotic hepatocytes with confluent and/or bridging necrosis	Severe: dense inflammatory infiltrate affecting >75% centrilobular areas

Blinded pathologist (MIF) examined twenty 10× fields per animal (n = 3 per group) and scored centrilobular necrosis and inflammation independently on 4-point scale (0–3). Data analyzed using two-tailed independent Student’s t-test and represented graphically as means±SEM in Fig. 1(G and H).