Table 4.

Conventional Cytogenetics and D-FISH Results Using a Homebrew MLL/ELL Probe for 18 Patients with t (11;19) (q23;p13.1)

		Conventional cytogenetic analysis	FISH analysis*
Patient no.	Age (years)	Karyotype	Abnormal nuclei (%)	Interphase signal pattern
66†	7 W	47,XY,+8,t (11;19) (q23;p13.1) [20]	82.6	1R1G2F
67	5 M	46,XY,t (2;19;11) (p11.2;p13.1;q23) [2]	2.8	2R2G1F
68	13	46,XX,t (2;12) (p11.2;q13),add(7) (p15),t (11;19) (q23;p13.1),add(17) (q25) [20]	91.2	1R1G2F
69†	20	46,XX,t (11;19) (q23;p13.1) [18]/46,XX[12]	71.4	1R1G2F
70	30	46,XX,t (11;19) (q23;p13.1) [7]/46,idem,add(13) (p12) [13]	56.4	1R1G2F
71†	34	47,XX,+8,t (11;19) (q23;p13.1),del(13) (q12q14) [20]	88.8	1R1G2F
72	44	46,XY,t (11;19) (q23;p13.1),−14,t (15;21) (q22;q22) [1]/46,XY[29]	12.8	1R1G2F
73	49	46,XX,t (11;19) (q23;p13.1) [19]/46,XX[1]	81.8	1R1G2F
74	51	46,XX,t (11;19) (q23;p13.1) [20]	96.8	1R1G2F
75	52	46,XX,t (11;19) (q23;p13.1) [21]	81.6	1R1G2F
76	55	46,XX,t (11;19) (q23;p13.1) [20]	80.6	1R1G2F
77†	55	46,XX,t (11;19) (q23;p13.1) [12]/46,XX[10]	50.4	1R1G2F
78†	58	45-48,XY,t (11;19) (q23;p13.1),+i(13) (q10) [cp25]/46,XY,i(17) (q10) [2]/ 46,XY[13]	96.8	1R1G2F
79	58	46,XX,t (11;19) (q23;p13.1) [20]	85	1R1G2F
80	60	46,XX,del(7) (q22),t (11;19) (q23;p13.1) [16]/46,XY[4]	47.6	1R1G2F
81	60	46,XY,t (11;19) (q23;p13.1) [20]	85.4	1R1G2F
82	68	46,XX,t (11;19) (q23;p13.1) [30]	94.8	1R1G2F
83	78	46,XX,t (11;19) (q23;p13.1) [20]	96.8	1R1G2F

F, fusion (yellow); G, green; M, months; R, red; W, weeks.

^*A total of 500 interphase nuclei were analyzed by two technologists (250 nuclei each).

^†The breakpoint for these patients was initially evaluated as 19p13.3.