Table 4.
Confusion Matrices and Accuracies for the Training and Independent Test Sets for the Three Second Tier Primary Site of Origin Classifiers
| Adenocarcinoma | ||||||
|---|---|---|---|---|---|---|
| Train–Test Split | ||||||
| Kidney | Ovary | Uterus | Colon | Lung | Prostate | Breast |
| 19 | 0 | 0 | 0 | 0 | 1 | 0 |
| 1 | 9 | 9 | 0 | 0 | 0 | 1 |
| 0 | 4 | 14 | 0 | 0 | 0 | 2 |
| 0 | 0 | 0 | 20 | 0 | 0 | 0 |
| 0 | 0 | 0 | 0 | 20 | 0 | 0 |
| 0 | 0 | 1 | 0 | 0 | 19 | 0 |
| 0 | 1 | 1 | 0 | 2 | 0 | 17 |
| CM Accuracy = 84% | ||||||
| Independent Test Set | ||||||
|---|---|---|---|---|---|---|
| Kidney | Ovary | Uterus | Colon | Lung | Prostate | Breast |
| 8 | 0 | 2 | 0 | 0 | 0 | 0 |
| 0 | 10 | 0 | 0 | 0 | 0 | 0 |
| 3 | 0 | 6 | 1 | 0 | 0 | 0 |
| 0 | 0 | 1 | 8 | 1 | 0 | 0 |
| 0 | 0 | 0 | 0 | 10 | 0 | 0 |
| 0 | 0 | 0 | 1 | 0 | 9 | 0 |
| 0 | 0 | 0 | 0 | 0 | 0 | 10 |
| CM Accuracy = 87% | ||||||
| Squamous | |||||
|---|---|---|---|---|---|
| Train–Test Split | |||||
| Tongue-larynx | Vulva | Cervix | Penis | Lung | Anal-rectum |
| 24 | 0 | 1 | 0 | 0 | 0 |
| 0 | 3 | 0 | 0 | 0 | 0 |
| 2 | 0 | 6 | 0 | 1 | 0 |
| 4 | 1 | 0 | 0 | 0 | 0 |
| 1 | 0 | 1 | 0 | 16 | 0 |
| 0 | 0 | 0 | 0 | 0 | 8 |
| CM Accuracy = 83% | |||||
| Independent Test Set | |||||
|---|---|---|---|---|---|
| Tongue-larynx | Vulva | Cervix | Penis | Lung | Anal-rectum |
| 11 | 0 | 0 | 0 | 0 | 0 |
| 2 | 0 | 0 | 0 | 0 | 0 |
| 0 | 0 | 6 | 0 | 0 | 0 |
| 0 | 0 | 0 | 1 | 1 | 0 |
| 0 | 0 | 0 | 0 | 4 | 0 |
| 0 | 0 | 0 | 0 | 0 | 4 |
| CM Accuracy = 90% | |||||
| Neuroendocrine | ||
|---|---|---|
| Train–Test Split | ||
| Small-bowel | Pancreas | Lung |
| 9 | 0 | 2 |
| 0 | 7 | 0 |
| 0 | 0 | 11 |
| CM Accuracy = 93% | ||
| Independent Test Set | ||
|---|---|---|
| Small-bowel | Pancreas | Lung |
| 4 | 0 | 1 |
| 0 | 4 | 0 |
| 0 | 0 | 11 |
| CM Accuracy = 87% | ||
Samples from the Moffitt and expO data sets were first grouped and tumors randomly selected for both training and independent validation.