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Characterization of the consensus splice sites surrounding the 42-nucleotide insertion. Uppercase and lowercase nucleotides corresponded respectively to pseudo-exonic and intronic sequences. The BCR-ABL breakpoint occurred nine nucleotides upstream of the insertion. Well-conserved consensus splice sites were recognized in the sequence: donor site in ABL intron Ib, acceptor site at the BCR-ABL breakpoint, potential lariat branch point and polypyrimidine tract in BCR intron 14.
