Original diagnostic findings |
|
Histology |
90% monoblasts on bone marrow biopsy |
Histochemistry |
Myeloperoxidase positive |
Flow cytometry |
Positive for CD4, CD14, CD64, CD36; partial positivity for CD13, CD15, CD33, HLA-DR, and MPO |
Cytogenetics |
t(11;19)(q23;p13) detected; negative for t(9;22), t(4;11), and inv16 |
Diagnostic findings at the time of “recurrence” |
|
Histology |
Blasts with large nuclei with 1–3 nucleoli; occasional cytoplasmic granules; no Auer rods |
Flow cytometry |
Positive for CD13, CD33, CD117, CD34, HLA-DR, CD4, CD7, CD38, and CD71 |
Cytogenetics |
Monosomy 7; negative for 11q23 translocation |