Figure 4.

Relation between changes in the number of hyperploid neurons and total neuronal loss in healthy controls and preclinical, mild, and severe AD. Hyperploid neurons are increased already in preclinical AD. They remain stable in number during transition from preclinical to mild AD and decrease with further progression of the disease. Linear regression analyses are indicated by dotted lines: 2, mild plus severe AD, r = 0.86, P < 0.001; 3, healthy controls, r = 0.71, P < 0.01; 4, preclinical AD, r = 0.50, n.s.; 5, preclinical plus mild AD, r = 0.36, n.s.