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. 2010 Jul;177(1):58–69. doi: 10.2353/ajpath.2010.091008

Figure 4.

Figure 4

Inhibition of PDGF-C confirms the pro-angiogenic role of PDGF-C in glomerular capillary repair. Rats treated with the PDGF antibody exhibited a significantly reduced mesangiolysis score (A), whereas the number of glomeruli exhibiting microaneurysms was not significantly, different (B). The group treated with the PDGF-C antibody exhibited a significantly reduced endothelial area positive for JG12 (C), as well as endothelial mitotic figures (D) and cells double positive for the endothelial cell marker JG12 and the proliferation marker PCNA (E). Graphs A–E show individual values of each animal (IgG group as triangles; PDGF-C antibody group as rectangles); the line depicts the mean value for each group. *P < 0.05; **P < 0.01.