Table 2.
Microarray Analysis of Isolated Glomeruli Taken at 6 Weeks of Age from Nonproteinuric Pod-Cre fVHL and Wild-Type Littermates
| Gene symbol | Gene name | Fold change | P |
|---|---|---|---|
| Glycolysis and gluconeogenesis | |||
| Ldha | Lactate dehydrogenase A | 1.56 | 0.003 |
| Pfkl | Phosphofructokinase, liver, B-type | 1.77 | 0.003 |
| Pkm2 | Pyruvate kinase, muscle | 2.14 | 0.00004 |
| Tpi1 | Triosephosphate isomerase 1 | 2.42 | 0.00002 |
| HIF1α signaling | |||
| Egln3 | EGL nine homolog 3 | 45.4 | 0.0002 |
| Ldha | Lactate dehydrogenase A | 1.56 | 0.003 |
| Mmp2 | Matrix metallopeptidase 2 | 1.54 | 0.05 |
| Slc2a1 | Solute carrier family 2 (facilitated glucose transporter), member 1 | 1.72 | 0.01 |
The genes listed are all increased in Pod-Cre fVHL mutant glomeruli (fold change) and are members of the top two networks identified in this dataset by Ingenuity Pathways Analysis.