Figure 3.

Loss of endogenous AnxA1 is involved in the inflammatory response elicited by CFTR₁₇₂. AnxA1^−/− and wild-type animals were treated with 50 μg/kg CFTR₁₇₂ 24 hours and one hour before the i.p. injection of 0.1 mg of zymosan or vehicle (PBS; 500 μl). Lavage fluids were collected four hours later. A: Total cell migration was assessed by light microscopy. B: Neutrophil migration was quantified after staining with an anti-Gr1 Ab and flow cytometry analysis. Data are mean ± SEM of five mice per group. *P < 0.05, **P < 0.01 vs. vehicle group.