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. 2010 Jul;177(1):229–239. doi: 10.2353/ajpath.2010.090821

Figure 6.

Figure 6

Effects of androgen ablation therapy on human prostate. Magnification for A, D, I, L, Q, T, Y, and AB is ×4, and for the rest of the images is ×40. In human prostate with short-term androgen ablation, normal glands with K18-expressing secretory cells (B and C) and p63 (R and S) and HMWK-expressing (Z and AA) basal cells were clearly identifiable. PSA expression in secretory cells was heterogeneous with intermediate (K) to no (J) staining. Involuting glands consisted of scattered K18-positive cells (G) and many p63- and HMWK-positive cells (W and AE, respectively). No PSA-positive cells were seen in these glands (O). The remaining cancer cells were K18-positive (E and F), p63-negative (U and V), and HMWK-negative (AC and AD). Similar to normal secretory cells, both positive- and negative-PSA staining were seen (M and N, respectively) in cancer cells. Note that the cancer cells with positive and negative PSA staining were adjacent to each other (L). Basal cell hyperplasia was observed in a subset of glands with multilayered p63-positive (X), HMWK-positive (AF) basal cells surrounding a single layer of K18-positive (H), and PSA-negative or -positive secretory cells (P).

HHS Vulnerability Disclosure