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. 2010 Jul;177(1):456–463. doi: 10.2353/ajpath.2010.090381

Figure 3.

Figure 3

CystC deficiency increases elastica degradation and SMC loss in the tunica media in AAA lesions. A: Microphotographs represent grading scale for elastica (Verhoeff–van Gieson). B: Evaluation of elastica degradation by grading (higher scores indicate larger breaks/ruptures in elastica) *P < 0.004. C: Microphotographs represent grading scale for SMCs (anti-mouse α-actin). D: Evaluation of SMC preservation by grading (higher scores indicate more irregularity and loss of SMC) *P < 0.04. E: Increased PDTC-induced apoptosis in SMCs isolated from CystC−/− aortas compared with control SMCs. Data present the percentage of apoptotic nuclei. F: Representative staining for apoptosis (TUNEL) in cross-sections from ApoE−/− (left) and CystC−/−ApoE−/− (right) suprarenal areas after five days of Ang II infusion. The arrowheads indicate apoptotic nuclei. G: Apoptotic SMC quantification. Data are presented as mean ± SE. Number of animals indicated in each bar *P < 0.04.