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. 2010 Jul;177(1):481–492. doi: 10.2353/ajpath.2010.090836

Figure 1.

Figure 1

Resveratrol inhibits CNV in mice in a Sirt1-independent manner. A: C57BL6 mice (n ≥ 5 per group) were treated with sham (vehicle-25% EtOH) or resveratrol (Res-22.5 mg/kg or 45 mg/kg) seven days before laser-induced injury, and treatment was continued for seven more days. CNV was quantified by confocal microscopy. B: Representative CNV lesions from sham- or resveratrol-treated mice. C: C57BL6 mice (n = 5 per group) were treated with sham (vehicle), resveratrol (45 mg/kg), Sirt1 Inh III (25 mg/kg), or resveratrol + Sirt1 Inh III for seven days before laser. Treatment was then continued for seven additional days after laser. CNV was quantified by confocal microscopy D: Representative CNV lesions from sham-treated, resveratrol-treated, or sirt1 inh III + resveratrol-treated mice. CNV volumes are average values ± SE. *P ≤ 0.05 by Student t test.