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. 2010 Jun 10;4:16. doi: 10.3389/fncel.2010.00016

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Copyright © 2010 Pinto, Hornby, Jones and Murphy.

This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.

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Developmental changes in GAD65 (A,B) and GAD67 (C,D) expression in human visual cortex across the lifespan plotted relative to the youngest age group (<1 year) for the grouped means and scattergrams (● average expression for each case; all runs). Example blots for each case are presented above the scattergrams (B,D). The arrow indicates the band that was quantified. A weighted average curve was fit to each scatter plots using the locally weighted least squares method at 50% (dotted line). GAD65 showed a significant change across the lifespan (Kruskal–Wallis, p < 0.0001) with progressive increase in expression levels into the teenage and adult years then a loss with aging (A,B). There was no change in expression levels of GAD67 across the lifespan (C,D). The lines above the histograms identify the groups that were significantly different (Tukey's post hoc HSD, *p < 0.05, **p < 0.02, ***p < 0.001).

Inline graphic — Developmental changes in GAD65 (A,B) and GAD67 (C,D) expression in human visual cortex across the lifespan plotted relative to the youngest age group (<1 year) for the grouped means and scattergrams (● average expression for each case; all runs). Example blots for each case are presented above the scattergrams (B,D). The arrow indicates the band that was quantified. A weighted average curve was fit to each scatter plots using the locally weighted least squares method at 50% (dotted line). GAD65 showed a significant change across the lifespan (Kruskal–Wallis, p < 0.0001) with progressive increase in expression levels into the teenage and adult years then a loss with aging (A,B). There was no change in expression levels of GAD67 across the lifespan (C,D). The lines above the histograms identify the groups that were significantly different (Tukey's post hoc HSD, *p < 0.05, **p < 0.02, ***p < 0.001).