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. 2010 Jun 10;4:16. doi: 10.3389/fncel.2010.00016

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Copyright © 2010 Pinto, Hornby, Jones and Murphy.

This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.

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Changes in expression of GABA_A receptor subunits GABA_Aα1 (A,B), GABA_Aα2 (C,D), and GABA_Aα3 (E,F) during postnatal development. An exponential decay function (solid line) was fit to the expression levels for GABA_Aα1 and GABA_Aα2 and the time constants (τ) were calculated with adult levels defined as 3τ. GABA_Aα1 expression increased until early teens when it leveled off (3τ = 13.5 years, τ = 4.50 years, R = 0.67; p < 0.0001; B). GABA_Aα2 expression decreased until older childhood when it leveled off (3τ = 10 years of age, τ = 3.34 years, R = 0.96; p < 0.0001; D). GABA_Aα3 expression levels did not change significantly throughout the lifespan (E,F) (dotted line is the weighted average). The lines above the histograms identify the groups that were significantly different (Tukey's post hoc HSD, *p < 0.05, **p < 0.02, ***p < 0.001) (● average expression for each case; all runs).

Inline graphic — Changes in expression of GABA_A receptor subunits GABA_Aα1 (A,B), GABA_Aα2 (C,D), and GABA_Aα3 (E,F) during postnatal development. An exponential decay function (solid line) was fit to the expression levels for GABA_Aα1 and GABA_Aα2 and the time constants (τ) were calculated with adult levels defined as 3τ. GABA_Aα1 expression increased until early teens when it leveled off (3τ = 13.5 years, τ = 4.50 years, R = 0.67; p < 0.0001; B). GABA_Aα2 expression decreased until older childhood when it leveled off (3τ = 10 years of age, τ = 3.34 years, R = 0.96; p < 0.0001; D). GABA_Aα3 expression levels did not change significantly throughout the lifespan (E,F) (dotted line is the weighted average). The lines above the histograms identify the groups that were significantly different (Tukey's post hoc HSD, *p < 0.05, **p < 0.02, ***p < 0.001) (● average expression for each case; all runs).