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Stromal MMP13 drives tumour growth and invasiveness in skin SCC. (A) Tumour growth curves of BDVII SCC cells upon s.c. injection into Mmp13+/+ and Mmp13−/− mice, **P < 0.001. (B) Immunostaining of blood vessels against CD31 (red), tumour tissue against pan-keratin (green) and nuclei by Hoechst (blue), bar 200 μm. (C) Analysis of cell proliferation by immunostaining of Ki67 (red), keratinized tumor areas (keratin, green) and nuclei (Hoechst, blue), bar 100 μm.
