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Proposed model for the effect of the inhibition of mTORC1 signaling by RAD001 in the thyroids of TRβPV/PVPten+/− mice. RAD001 significantly inhibits the activity of the mTORC1 downstream targets belonging to the translation initiation machinery. Whereas the treatment did not inhibit cell migration to prevent cancer progression or exert noticeable proapoptotic actions, it consistently reduced cell proliferation, thereby reducing thyroid cancer growth to augment mouse life span.
