Table II.
Results of the pathway analyses
| Pathway | Number of genes | Number of SNPs | Nominal P-valuea | Bonferroni P-value |
| Carcinogens /procarcinogens metabolism | 71 | 201 | 0.0119 | 0.1663 |
| DNA repair | 51 | 133 | 0.2218 | 1.0000 |
| Cell cycle control | 48 | 166 | 0.0417 | 0.5832 |
| Apoptosis | 41 | 234 | 0.0004 | 0.0062 |
| Inflammation | 37 | 224 | 0.0725 | 1.0000 |
| Cell growth | 30 | 63 | 0.6744 | 1.0000 |
| Cell signaling | 28 | 83 | 0.5267 | 1.0000 |
| Angiogenesis | 15 | 145 | 0.2296 | 1.0000 |
| Metastasis | 15 | 18 | 0.4344 | 1.0000 |
| Sex hormone signaling | 11 | 65 | 0.0583 | 0.8160 |
| Immunity | 10 | 20 | 0.8972 | 1.0000 |
| Molecular transport | 8 | 16 | 0.2100 | 1.0000 |
| DNA methylation | 4 | 14 | 0.2667 | 1.0000 |
| Telomere maintenance | 1 | 5 | 0.0174 | 0.2432 |
a
Pathway-based analysis assessed by the logistic kernel machine regression adjusted for age and sex. Significant pathway effect after correcting for multiple comparisons is indicated in bold.