Table II.
Associations between NBS1 SNPs and smoking-related cancers, stratified by cancer site
| SNP | rs709816 (D399D) |
rs1061302 (P672P) |
rs1063054 (3' UTR) |
|||||
| Case/control | ORadj (95% CI)a | Genotype | Case/control | ORadj (95% CI)a | Genotype | Case/control | ORadj (95% CI)a | |
| LA study | ||||||||
| Lung | ||||||||
| TT | 156/278 | 1.0 | AA | 265/407 | 1.0 | AA | 241/411 | 1.0 |
| TC | 230/421 | 0.88 (0.65, 1.2) | AG | 196/414 | 0.74 (0.56, 0.98) | AC | 226/427 | 0.88 (0.67, 1.2) |
| CC | 127/194 | 1.0 (0.70, 1.5) | GG | 72/95 | 1.6 (1.0, 2.4) | CC | 72/80 | 1.5 (0.96, 2.3) |
| Ptrend | 0.97 | Ptrend | 0.45 | Ptrend | 0.39 | |||
| Dominant | 357/615 | 0.92 (0.68, 1.2) | Dominant | 268/509 | 0.88 (0.68, 1.2) | Dominant | 298/507 | 0.96 (0.74, 1.2) |
| Recessive | 127/194 | 1.1 (0.81, 1.6) | Recessive | 72/95 | 1.8 (1.2, 2.7) | Recessive | 72/80 | 1.6 (1.0, 2.3) |
| UADT (squamous) | ||||||||
| TT | 107/283 | 1.0 | AA | 174/413 | 1.0 | AA | 170/415 | 1.0 |
| TC | 194/423 | 1.1 (0.81, 1.5) | AG | 184/415 | 1.0 (0.79, 1.3) | AC | 200/430 | 1.1 (0.86, 1.5) |
| CC | 80/196 | 0.95 (0.64, 1.4) | GG | 38/97 | 0.82 (0.52, 1.3) | CC | 33/82 | 0.95 (0.59, 1.5) |
| Ptrend | 0.90 | Ptrend | 0.60 | Ptrend | 0.60 | |||
| Dominant | 274/619 | 1.1 (0.79, 1.4) | Dominant | 222/512 | 0.99 (0.76, 1.3) | Dominant | 233/512 | 1.0 (0.84, 1.4) |
| Recessive | 80/196 | 0.89 (0.64, 1.3) | Recessive | 38/97 | 0.81 (0.52, 1.2) | Recessive | 33/82 | 0.89 (0.57, 1.4) |
| UADT stratified | ||||||||
| Oropharynx | ||||||||
| TT | 63/283 | 1.0 | AA | 97/413 | 1.0 | AA | 94/415 | 1.0 |
| TC | 117/423 | 1.2 (0.83, 1.7) | AG | 114/415 | 1.2 (0.84, 1.6) | AC | 119/430 | 1.2 (0.86, 1.6) |
| CC | 45/196 | 1.0 (0.65, 1.7) | GG | 24/97 | 0.96 (0.56, 1.7) | CC | 27/82 | 1.4 (0.81, 2.3) |
| Ptrend | 0.73 | Ptrend | 0.74 | Ptrend | 0.19 | |||
| Dominant | 162/619 | 1.2 (0.82, 1.7) | Dominant | 138/512 | 1.1 (0.82, 1.5) | Dominant | 146/512 | 1.2 (0.88, 1.6) |
| Recessive | 45/196 | 0.92 (0.62, 1.4) | Recessive | 24/97 | 0.89 (0.54, 1.5) | Recessive | 27/82 | 1.2 (0.75, 2.0) |
| Larynx | ||||||||
| TT | 24/283 | 1.0 | AA | 41/413 | 1.0 | AA | 36/415 | 1.0 |
| TC | 35/423 | 0.65 (0.34, 1.2) | AG | 28/415 | 0.54 (0.30, 0.98) | AC | 39/430 | 0.91 (0.53, 1.6) |
| CC | 17/196 | 0.49 (0.21, 1.1) | GG | 7/97 | 0.62 (0.24, 1.6) | CC | 2/82 | 0.25 (0.05, 1.2) |
| Ptrend | 0.080 | Ptrend | 0.079 | Ptrend | 0.16 | |||
| Dominant | 52/619 | 0.60 (0.33, 1.1) | Dominant | 35/512 | 0.56 (0.32, 0.97) | Dominant | 41/512 | 0.80 (0.47, 1.4) |
| Recessive | 17/196 | 0.66 (0.33, 1.3) | Recessive | 7/97 | 0.82 (0.32, 2.1) | Recessive | 2/82 | 0.28 (0.06, 1.2) |
| MSKCC | ||||||||
| Bladder | ||||||||
| TT | 40/63 | 1.0 | AA | 75/85 | 1.0 | AA | 90/88 | 1.0 |
| TC | 79/58 | 1.0 (0.43, 2.4) | AG | 83/58 | 0.97 (0.48, 2.0) | AC | 76/60 | 1.3 (0.64, 2.6) |
| CC | 29/29 | 4.2 (1.3, 14) | GG | 19/24 | 1.7 (0.56, 5.4) | CC | 10/20 | 2.3 (0.57, 9.2) |
| Ptrend | 0.037 | Ptrend | 0.50 | Ptrend | 0.24 | |||
| Dominant | 108/87 | 1.5 (0.68, 3.2) | Dominant | 102/82 | 1.1 (0.56, 2.1) | Dominant | 86/80 | 1.4 (0.71, 2.7) |
| Recessive | 29/29 | 4.2 (1.4, 12) | Recessive | 19/24 | 1.8 (0.59, 5.3) | Recessive | 10/20 | 2.1 (0.54, 8.1) |
| Taixing studyb | ||||||||
| Esophagus | ||||||||
| AA | 72/140 | 1.0 | AA | 74/152 | 1.0 | |||
| AG | 93/169 | 0.97 (0.63, 1.5) | AC | 95/178 | 1.0 (0.78, 1.6) | |||
| GG | 36/69 | 1.0 (0.59, 1.8) | CC | 32/52 | 1.4 (0.78, 2.5) | |||
| Ptrend | 0.89 | Ptrend | 0.33 | |||||
| Dominant | 129/238 | 0.98 (0.66, 1.5) | Dominant | 127/230 | 1.1 (0.75, 1.7) | |||
| Recessive | 36/69 | 1.0 (0.63, 1.7) | Recessive | 32/52 | 1.4 (0.80, 2.3) | |||
| Stomach | ||||||||
| AA | 54/140 | 1.0 | AA | 66/152 | 1.0 | |||
| AG | 96/169 | 1.3 (0.82, 2.0) | AC | 97/178 | 1.2 (0.77, 1.8) | |||
| GG | 38/69 | 1.2 (0.70, 2.2) | CC | 26/52 | 1.2 (0.63, 2.2) | |||
| Ptrend | 0.37 | Ptrend | 0.61 | |||||
| Dominant | 134/238 | 1.3 (0.82, 2.0) | Dominant | 123/230 | 1.2 (0.79, 1.8) | |||
| Recessive | 38/69 | 1.1 (0.65, 1.7) | Recessive | 26/52 | 1.1 (0.60, 1.9) | |||
| Liver | ||||||||
| AA | 52/140 | 1.0 | AA | 67/152 | 1.0 | |||
| AG | 94/169 | 1.2 (0.75, 2.0) | AC | 90/178 | 1.1 (0.72, 1.8) | |||
| GG | 39/69 | 1.9 (1.1, 3.5) | CC | 32/52 | 1.8 (0.98, 3.4) | |||
| Ptrend | 0.034 | Ptrend | 0.092 | |||||
| Dominant | 133/238 | 1.4 (0.89, 2.2) | Dominant | 122/230 | 1.3 (0.83, 1.9) | |||
| Recessive | 39/69 | 1.7 (1.0, 2.9) | Recessive | 32/52 | 1.7 (0.96, 3.0) | |||
UTR, untranslated region.
a
LA study: lung cancer adjusted for gender, smoking, education, race and age; UADT cancers additionally adjusted for alcohol drinking; MSKCC Study: bladder cancers adjusted for gender, smoking, race, education and age. Taixing study: esophageal cancer adjusted for gender, smoking, age, alcohol drinking and education; stomach and liver cancers additionally adjusted for helicobacter pylori infection and HBsAg status, respectively.
b
rs709816 (D399) not genotyped in Taixing study.