Table III.

Modifications of SNPs and smoking status on the association of selected SNPs and smoking-related cancer sites

	Cases/controls				OR (95% CI)a
Lung
rs1061302	Genotype	A/A	A/G	G/G	A/A	A/G	G/G
Smoking status	Never	34/194	39/189	19/47	1.0	1.4 (0.82, 2.4)	2.4 (1.2, 4.9)
	Ever	231/213	157/225	53/48	1.7 (1.0, 2.8)	1.0 (0.60, 1.7)	2.3 (1.2, 4.3)
	Genotype-specific RORadj (95% CI)					0.41 (0.22, 0.77)b	0.56 (0.24, 1.4)c
	Genotype-combined RORadj (95% CI)					1.0 (0.92, 1.2)d
rs709816		T/T	T/C and C/C		T/T	T/C and C/C
Smoking status	Never	17/137	72/285		1.0	1.6 (0.90, 3.0)
	Ever	139/141	285/330		2.0 (1.1, 3.8)	1.5 (0.82, 2.8)
	RORadj (95% CI)					0.46 (0.23, 0.90)
Stomach
rs1063054		A/A	A/C & C/C		A/A	A/C & C/C
Smoking status	Never	33/71	51/125		1.0	0.77 (0.43, 1.4)
	Ever	30/80	70/105		0.64 (0.27, 1.5)	1.1 (0.50, 2.5)
	RORadj (95% CI)					2.3 (1.0, 5.3)

^aLung cancer adjusted for gender, smoking, education, race and age; stomach cancer adjusted for gender, smoking, age, alcohol drinking, helicobacter pylori infection and education.

^bROR_adj (95% CI) for rs1061302 A/G genotype and smoking, with A/A plus never-smoker as referent.

^cROR_adj (95% CI) for rs1061302 G/G genotype and smoking, with A/A plus never-smoker as referent.

^dROR_adj (95% CI) for rs1061302 genotypes-combined and smoking, with A/A plus never-smoker as referent.