Table 2.

Effects of age and TNFR1 rs4149573 genotype on CADi in 1811 CATHGEN subjects

Linear regression model component	Linear regression model [regression coefficient (SE), and P-value for the Wald test]
	Clinical variables only	Clinical variables + SNP genotype	Clinical variables + SNP genotype + age × genotype
Age	0.65 (0.06), <0.0001	0.65 (0.06), <0.0001	0.58 (0.06), <0.0001
rs4149573 CG/GG genotypes	Not in model	−1.33 (2.34), 0.57	−25.32 (9.53), 0.0079
Age × genotype interaction	Not in model	Not in model	0.44 (0.14), 0.0032
Intercept	16.27 (6.22), 0.0090	17.54 (6.72), 0.0091	20.55 (6.24), 0.0010
Gender (F)	−11.42 (6.26), <0.0001	−11.45 (1.54), <0.0001	−11.55 (1.54), <0.0001
Race (AA)	2.78 (1.94), 0.15	2.79 (1.95), 0.15	2.51 (1.95), 0.20
History of diabetesa	6.51 (1.83), 0.0004	6.59 (1.82), 0.0003	6.62 (1.83), 0.0003
History of smoking	5.88 (1.53), 0.0001	5.87 (1.53), 0.0001	5.90 (1.52), 0.0001
BMI (kg/m2)	−0.19 (0.11), 0.09	−0.19 (0.11), 0.09	−0.18 (0.11), 0.11
History of hypertension	2.53 (1.79), 0.16	2.55 (1.79), 0.15	2.45 (1.77), 0.17
History of hyperlipidemia	12.09 (1.68), <0.0001	12.08 (1.69), <0.0001	12.15 (1.67), <0.0001

SNP genotype, TNFR1 rs4149573 genotype; age × genotype, age-by-genotype interaction term; F, female; AA, African American.

^aDetermined by clinical history.