Table 4.

Adjusted HRs and 95% CIs for Prostate Cancer Among 19,106 Men With and Without Male Factor Infertility From a Cohort of Couples Evaluated for Infertility^a

		Prostate Cancer
	No.	no.	%	Unadjusted HR (95% CI)	P	Adjusted HRb (95% CI)	P
All prostate cancers
Male factor infertility
No	14,557	64	0.44	1.0 (referent)	–	1.0 (referent)	–
Yes	4549	56	1.23	2.8 (2.0-4.0)	<.0001	1.8 (1.2-2.5)	.0010
Low-grade prostate cancer c
Male factor infertility
No	14,557	47	0.32	1.0 (referent)	–	1.0 (referent)	–
Yes	4549	37	0.81	2.5 (1.6-3.9)	<.0001	1.6 (1.0-2.4)	.042
High-grade prostate cancer d
Male factor infertility
No	14,557	16	0.11	1.0 (referent)	–	1.0 (referent)	–
Yes	4549	19	0.42	3.8 (1.9-7.3)	<.0001	2.6 (1.4-4.8)	.0032

HRs indicates hazard ratios; 95% CIs, 95% confidence intervals.

^aA total of 3456 men were excluded from analysis because of unknown male factor infertility status.

^bAdjusted for age, infertility treatment duration, and infertility treatment facility.

^cSurveillance, Epidemiology, and End Results (SEER) grade 2: moderately well-differentiated, Gleason score of 5 to 7.

^dSEER grade 3: poorly differentiated, Gleason score of 8 to 10.