Table 3. Estimated PFK and PK inhibition factor.
PFK and PK inhibition factors were estimated for two conditions: the upper and lower boundary of the ATP consumption rate at rest, 0.75µM/s and 0.1µM/s, respectively, yielding an upper and lower boundary for the estimated PFK and PK inhibition factors. Steady state metabolite concentrations ([G6P], [F-1,6P2] and [ADP]) predicted by the model that included the inhibition factors are also listed.
| PFK inhibition |
PK inhibition |
[G6P] [mM] |
[F-1,6P2] [mM] |
[ADP] [mM] |
|
|---|---|---|---|---|---|
|
Upper bound |
0.030 | 0.021 | 0.38 | 0.056 | 0.009 |
|
Lower bound |
0.0037 | 0.0027 | 0.40 | 0.052 | 0.010 |