Table 1. Nonclassical CD8+ T-cell clones predominate in TB-uninfected individuals.
Donor Status | Donor ID | Frequencies of Mtb-specific CD8+ cellsa | n Clones Screened | Percent Classical | Percent Nonclassical |
Active | D431 | 1/403 | 109 | 60 | 40 |
D432 | 1/1156 | 191 | 50 | 50 | |
D435 | 1/664 | 17 | 24 | 76 | |
D466 | 1/528 | 167 | 95 | 5 | |
D480 | 1/418 | 192 | 59 | 41 | |
D481 | 1/618 | 159 | 96 | 4 | |
n = 6 | — | — | — | 64% | 36% |
LTBI | D426 | 1/6956 | 24 | 0 | 100 |
D443 | 1/1002 | 7 | 43 | 57 | |
D450 | 1/1102 | 192 | 16 | 84 | |
D454 | 1/1818 | 192 | 70 | 30 | |
D504 | 1/1978 | 192 | 16 | 84 | |
n = 5 | — | — | — | 29% | 71% |
Uninfected | D403 | 1/2148 | 92 | 16 | 84 |
D470 | 1/1774 | 192 | 4 | 96 | |
D462 | N.D. | 86 | 18 | 83 | |
D427 | 1/7568 | 192 | 27 | 73 | |
D497 | 1/3126 | 53 | 10 | 90 | |
n = 5 | — | — | — | 15% | 85% |
These frequencies were previously reported [4].
Abbreviations: N.D., not done.