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. 2010 Jun 29;8(6):e1000408. doi: 10.1371/journal.pbio.1000408

Figure 8. Sensitivity of lymphoblast cell lines to DNA damaging agents.

Figure 8

(A) Growth curves of a control lymphoblast cell line—MHU-2619 (solid line), a cell line carrying the KIAA0415 mutation—FSP-083-4 (dotted line) without drug treatment (black line) or MMC treatment (light grey), are presented. (B and C) Cell lines derived from patients with a mutation in KIAA0415 and SPG15 are more sensitive to DNA damaging drugs. The decrease of viable cells (propidium iodide and Annexin V negative) is shown in percent (grey bar) for the indicated cell lines after MMC treatment (B) and bleomycin treatment (C). *p<0.05.