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Ubr1 functions in the degradation of newly synthesized protein kinases when Hsp90 is inhibited with geldanamycin. (A) Pulse-chase analysis of HA-Tpk2 in wild-type cells treated with geldanamycin (GA; 50 μM) and the proteasome inhibitor, MG132 (100 μM) or solvent alone. (B) Pulse-chase analysis of HA-tagged Tpk2 in wild-type and ubr1Δ cells treated with GA. Chase times shown in minutes. (C) Graph of HA-Tpk2 degradation (n = 3; error bars, ±SE).
