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. Author manuscript; available in PMC: 2010 Jun 30.
Published in final edited form as: Mol Cell. 2000 Apr;5(4):737–744. doi: 10.1016/s1097-2765(00)80252-x

Figure 4.

Figure 4

p48 Suppresses Mutations Arising from Pyrimidine Dimers in the Nontranscribed Strand of DNA

(A) Strand bias. UV-induced mutations in the HPRT gene were measured in hamster cells stably transfected with vector or p48. The percentage of mutations on the transcribed strand (TS) and nontranscribed strand (NTS) was multiplied by the overall mutation rates to obtain strand-specific mutation rates. (B) TT versus non-TT bias. Mutation rates are shown for TT and non-TT dipyrimidine sequences. Cases in which the dipyrimidine could have been either TT or non-TT (Table 1) were all on the NTS, and these were not included in the analysis.