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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Neurobiol Aging. 2010 Feb 4;32(12):2287–2298. doi: 10.1016/j.neurobiolaging.2010.01.003

Figure 3.

Figure 3

The C-terminal domain of the amyloid-β precursor protein is co-localized with Hirano bodies. H4 stable cells expressing (A) CT-GFP or (B) GFP were transiently transfected with APPc58-myc and visualized by anti-myc, and TRITC-conjugated secondary antibody (red) for APPc58-myc. DNA was stained with Hoechst dye (blue). A. Areas of specific co-localization of APPc58-myc with Hirano bodies in the cytoplasm in CT-GFP stable cells appear yellow in the merged images. B. APPc58-myc is strongly localized in the nucleus in GFP stable cells. Scale bar = 20 μm.