Skip to main content
. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Aging Cell. 2010 Mar 12;9(3):347–357. doi: 10.1111/j.1474-9726.2010.00559.x

Figure 3. Accelerated thymic involution, and rapidly reduced cell numbers in uCreERT-fx/fx mice correlated with age.

Figure 3

(A) A gross representation of thymic size in WT mice at 2, 9, 14, and 22 months of age and fx/fx-only (without Cre-recombinase) mice at 9 months of age. (B) A gross representation of thymic size in fx/fx-only (without Cre-recombinase), uCreERT-fx/+, and uCreERT-fx/fx mice at 1, 3, and 5 months of age. (C) The linear regression for DP thymocyte numbers correlated with age. (D) The linear regression for CD4+SP numbers correlated with age. Both C and D panels include 25 fx/fx-only (without Cre-recombinase) mice, each circle = one mouse, p = 0.008 in DP cells (panel C) and p = 0.52 in CD4+SP cells (panel D); 32 uCreERT-fx/+ mice, each triangle = one mouse, p = 0.004 in DP cells (panel C) and p = 0.004 in CD4+SP cells (panel D); and 16 uCreERT-fx/fx mice, each square = one mouse, p = 0.01 in DP cells (panel C) and p = 0.03 in CD4+SP cells (panel D).