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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Aging Cell. 2010 Mar 12;9(3):347–357. doi: 10.1111/j.1474-9726.2010.00559.x

Figure 6. Accelerated loss of MHC-IIhiUEA-1hi mTECs with gradual FoxN1-deletion in uCreERT-fx/fx mice during aging.

Figure 6

(A) A representative flow cytometry plot of staining for CD45−MHC-IIhiUEA-1hi mTECs (gate A) in thymi from uCreERT-fx/fx mice at ~1, ~3, and ~6 months of age. (B) Summarized results of MHC-IIhiUEA-1hi mTEC absolute numbers in fx/fx-only (without Cre-recombinase), uCreERT-fx/+, and uCreERT-fx/fx mice with linear regression analysis. r2 = correlation of cell numbers to age; p < 0.05 = significant correlation. (C) t-test of MHC-IIhiUEA-1hi mTEC absolute numbers at 3–6 months of age from the three groups of mice as in panel B.