TABLE 1.
PATIENT DATA FROM 63 PARTICIPANTS PROVIDING LUNG TISSUE
| GOLD Stage | 0 (Control) | 1 (Mild) | 2 (Moderate) | 3–4 (Severe) |
|---|---|---|---|---|
| Origin of lung tissue | Van | Van | Van | 4 Van, 8 SL |
| Location of lung tissues examined | 3 RUL | 4 RUL | 4 RUL | 2 RUL |
| 4 RLL | 4 RLL | 2 RLL | 2 RLL | |
| 6 LUL | 4 LUL | 7 LUL | 4 LUL | |
| 3 LLL | 6 LLL | 4 LLL | 4 LLL | |
| No. of cases | 16 | 18 | 17 | 12 |
| No. of airways and surrounding tissues examined | 35 | 37 | 36 | 28 |
| FEV1/FVC, mean ± SD | 78.2 ± 4.1 | 65.5 ± 3.6 | 58.8 ± 6.2 | 46.0 ± 12.8 |
| FEV1, mean ± SD | 96.2 ± 8.5 | 92.1 ± 8.9 | 65.6 ± 6.7 | 27.7 ± 12.0 |
| Pack-years, mean ± SD | 36.8 ± 17.2 | 50.9 ± 19.5 | 50.7 ± 30.6 | 49.9 ± 14.4 |
| Former smokers | 6 | 5 (2 n/a) | 2 | 8 (2 n/a) |
| Years stopped smoking, mean ± SD | 15.0 ± 10.3 | 7.4 ± 5.8 | 4.0 ± 4.2 | 5.4 ± 4.7 |
| Steroid treatment, no. of patients | 2 (2 n/a) | 1 (3 n/a) | 0 | 7 (1 n/a) |
| Age, mean ± SD | 64.7 ± 8.5 | 63.6 ± 10.4 | 60.8 ± 9.0 | 60.4 ± 7.8 |
Definition of abbreviations: GOLD = Global Initiative for Chronic Obstructive Lung Disease; LLL = left lower lobe; LUL = left upper lobe; n/a = data not available; RLL = right lower lobe; RUL = right upper lobe; SL = Barnes Jewish Hospital (St. Louis, MO); Van = St. Paul's Hospital (Vancouver, Canada).