TABLE 5.

PULMONARY FUNCTION, RADIOLOGIC APPEARANCE, SERUM BIOMARKERS, AND HEMATOLOGIC INDICES IN PATIENTS WITH PULMONARY ALVEOLAR PROTEINOSIS OF RESPONDERS AND NONRESPONDERS

	Responder		Nonresponder
	n	Mean ± SE or Median (I.Q. range)*	n	Mean ± SE or Median (I.Q. range)	P Value
Pulmonary function
VC, % predicted	24	81.5 ± 3.0	11	79.9 ± 4.6	0.77†
FVC, % predicted	24	81.3 ± 3.0	11	78.8 ± 4.7	0.66†
FEV1/FVC	24	88.3 ± 2.1	11	82.2 ± 1.8	0.07†
DlCO, % predicted	22	54.5 ± 4.0	11	52.0 ± 3.9	0.68†
HRCT scores (all patients receiving treatment)
Upper lung region	24	3 (2–5)	11	3 (2–5)	0.82‡
Middle lung region	24	4 (3–5)	11	4 (2–4.25)	0.59‡
Lower lung region	24	4 (3–5)	11	4 (3.75–5)	0.91‡
Serum biomarkers of PAP
LDH, IU/L	24	307 ± 20	11	285 ± 24	0.51†
CEA, ng/ml	24	7.3 ± 1.1	11	5.8 ± 1.1	0.38†
KL-6, U/L	24	11,531 ± 1,576	11	6,121 ± 1,316	0.04†
SP-A, ng/ml	24	136 ± 15	11	134 ± 24	0.92†
SP-D, ng/ml	24	261 ± 25	11	223 ± 40	0.38†
Hematologic indices
White blood count, cells/μl	24	5,948 ± 302	11	5,685 ± 266	0.59†
Neutrophils, cells/μl	24	3,465 ± 210	10	3,542 ± 214	0.83†
Monocytes, cells/μl	24	375 ± 22	10	331 ± 20	0.24†
Lymphocytes, cells/μl	24	1,934 ± 154	10	1,710 ± 176	0.41†
Eosinophils, cells/μl	24	145 ± 25	10	126 ± 54	0.73†
Hemoglobin, g/dl	24	14.9 ± 0.3	11	15.4 ± 0.4	0.38†
Platelets, ×103 cells/μl	24	234 ± 9.2	11	255 ± 17	0.23†

Definition of abbreviations: CEA = carcinoembryonic antigen; Dl_CO = diffusing capacity of carbon monoxide; HRCT = high-resolution computed tomography; KL-6 = a mucin-like glycoprotein; LDH = lactate dehydrogenase; SP = surfactant protein.

^*Interquartile (I.Q.) range is the range from the 25th to the 75th percentiles of the distribution.

^†Calculated using Student t test.

^‡Calculated using the Wilcoxon rank sum test.