Figure 5.

Average electroencephalographic (EEG) power spectra during microdialysis with Ringer's solution in freely moving rat before and after intravenous (i.v.) eszopiclone administration. Each power spectrum is an average from the same 3 rats used to obtain acetylcholine (ACh) release measures (Figure 4B). Insets show representative 10-s EEG recordings after i.v. administration of eszopiclone or during no drug treatment. EEG delta power was significantly (*) increased during (A) wakefulness (0.5 to 2 Hz) and (B) non-rapid eye movement (NREM) sleep (0.5 to 1.5 Hz). C. Rats did not have rapid eye movement (REM) sleep after i.v. administration of eszopiclone.