Table I.

A survey of disease states associated with defects in engulfment-related genes

Gene	Disease relationship	Human/mouse	References
Find me
G2A	AI	M	Le et al., 2001
CX3CR1	Neuropathy	M	Cardona et al., 2006
CX3CL1	Atherosclerosis	M	Combadière et al., 2003
Eat-me/tickling
MER	AI, cancer, neuropathy, atherosclerosis	H/M	Gal et al., 2000; Scott et al., 2001; Cohen et al., 2002; Keating et al., 2006; Nandrot et al., 2007; Ait-Oufella et al., 2008; Thorp et al., 2008
MFG-E8	AI, atherosclerosis, neuropathy	M	Hanayama et al., 2004; Ait-Oufella et al., 2007; Nandrot et al., 2007
C1q	AI, atherosclerosis, neuropathy	M	Botto et al., 1998; Fonseca et al., 2004; Bhatia et al., 2007
αvβ3/5	AI, atherosclerosis	M	Weng et al., 2003; Lacy-Hulbert et al., 2007
TIM-4	AI	M	Rodriguez-Manzanet et al., 2010
Gas6	Atherosclerosis	M	Lutgens et al., 2008
Engulfment
ELMO1	Diabetic nephropathya	H	Shimazaki et al., 2005; Leak et al., 2009; Pezzolesi et al., 2009a
GULP1	Arthritisa, schizophreniaa	H	Qingchun et al., 2008; Chen et al., 2009
MEGF10	Schizophreniaa	H	Chen et al., 2009
Post-engulfment
LXRα/β	AI	M	A-Gonzalez et al., 2009
PPARδ	AI	M	Mukundan et al., 2009
DNase II	AI	M	Kawane et al., 2003

Genes are grouped by known roles in engulfment (find-me, eat-me, engulfment, and post-engulfment). AI, autoimmune phenotype; H, human; M, mouse.

^aThere is evidence of genetic linkage but no direct causal relationship was established.