Table 1.

Metabolic pathways altered by diet in the humanized mouse gut microbiome^*.

KEGG Pathways Enriched on LF/PP diet	Cyanoamino acid metabolism
	Glycosaminoglycan degradation
	Glycosphingolipid biosynthesis - ganglioseries
	N-Glycan degradation
	Nucleotide sugars metabolism
	Other ion-coupled transporters
	Pentose and glucuronate interconversions
	Phenylpropanoid biosynthesis
	Sphingolipid metabolism
	Starch and sucrose metabolism
KEGG Pathways Enriched on Western diet	ABC transporters
	Phosphotransferase system (PTS)
	Transporters

^*Based on a bootstrap analysis of gut microbiome datasets from humanized mice fed the LF/PP diet (7–35 dpc) or the Western diet (29–35dpc; CI=0.95, 10,000 samples; inclusion criterion, pathways must be found at ≥0.6% relative abundance in at least two samples) dpc, days post colonization with a human fecal sample