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. Author manuscript; available in PMC: 2011 Jun 15.
Published in final edited form as: Anal Chem. 2010 Jun 15;82(12):5260–5267. doi: 10.1021/ac100669z

Figure 6.

Figure 6

Comparison of RICs of 3 co-eluting components fumarate (m/z 115), succinate (m/z 117) and malate (m/z 133) without and with peak parking. Different time scales for three groups of chromatograms were marked at the bottom of each figure. (A) On-line detection of the 3 compounds with QQQ-MS. (B) Off-line detection of the 3 compounds in segmented flow at 500 nL/min, the same flow rate as the original on-line detection. These peaks were narrow, resulting in only 1–5 scans covering each sample peak. Top figure showed rough sample droplets distribution. (C) Off-line detection of the 3 compounds in segmented flow by reducing flow rate to 50 nL/min right before the three peaks, resulting in more scan numbers over each sample peak.