Table 4. Comparison of 4 Hormone Measures as Predictors of Change in Components of the MetS, After Adjustment for Standard Risk Factors^a.

	Outcome, Standardized β Coefficient
Measure	Δ Waist Circumference	Δ HDL-C Level	Δ Glucose Level	Δ Triglyceride Level	Δ SBP
Estradiol level
Δ	−0.04	0.69b	−0.30	0.17	−0.41c
Baseline	0.10	0.14	−0.25	−2.40c	−0.15
Testosterone level
Δ	−0.03	0.20	0.75b	1.92d	−0.04
Baseline	−0.01	−0.03	−0.04	0.94	0.49d
SHBG level
Δ	−0.21b	0.81b	−0.40d	0.09	−0.23
Baseline	−0.10	0.37	−0.07	−0.54	0.13
Bioavailable testosterone level
Δ	0.14c	−0.48c	0.81b	1.14	0.12
Baseline	0.08	−0.35	0.01	0.89	0.23

Abbreviations: Δ, change; HDL-C, high-density lipoprotein cholesterol; MetS, metabolic syndrome; SBP, systolic blood pressure; SHBG, sex hormone–binding globulin.

^aCovariates are the baseline outcome (P≤.001), age at final menstrual period (P≤.001), aging (P≤.001), ethnicity, study site, education, marital status, smoking, baseline body mass index (BMI) (P≤.001), and change in BMI from baseline (P≤.001). Significance levels of these covariates do not vary across models.

^bP≤.001.

^cP≤.01.

^dP≤.05.