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. Author manuscript; available in PMC: 2010 Jun 30.

Published in final edited form as: J Med Chem. 2007 Aug 28;50(19):4585–4605. doi: 10.1021/jm0703340

Table 7.

6-CN-THQs with a Variation of R₃


	Syn. Scheme	R₁	R₂	R₃	Pf-PFT % Inhibition at			ED₅₀ (nM)
Comp					50 nM	5 nM	0.5 nM	3D7	K1
252	4				94			120
253	4				93			120
254	4					45	22	150	140
255	5				0	0	0	>5000	3200
34	8				96	79	12	650	650
256	4				35	12	3	3400	3000