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Gastrin receptor-targeted CPNPs effectively targeted human BxPC-3 pancreatic cancer cells. BxPC-3 cells were exposed to fluorescein-loaded untargeted PEG-CPNPs, or Gastrin- 10-PEG-CPNPs, for 5 minutes followed by exchange to fresh media for 55 minutes, or exposure for 60 minutes. (A) Cells were fixed and visualized by microscopy. (B) Cells were fixed and analyzed by flow cytometry with graphs representing 10,000 collected events per sample.
